Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection
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چکیده
منابع مشابه
Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection.
Spinal Wistar Hannover rats injected with olfactory ensheathing glia (OEG) have been shown to recover some bipedal stepping and climbing abilities. Given the intrinsic ability of the spinal cord to regain stepping with pharmacological agents or epidural stimulation after a complete mid-thoracic transection, we asked if functional recovery after OEG injections is due to changes in the caudal stu...
متن کاملMotor axonal regeneration after partial and complete spinal cord transection.
We subjected rats to either partial midcervical or complete upper thoracic spinal cord transections and examined whether combinatorial treatments support motor axonal regeneration into and beyond the lesion. Subjects received cAMP injections into brainstem reticular motor neurons to stimulate their endogenous growth state, bone marrow stromal cell grafts in lesion sites to provide permissive ma...
متن کاملNoradrenergic innervation of the rat spinal cord caudal to a complete spinal cord transection: effects of olfactory ensheathing glia.
Transplantation of olfactory bulb-derived olfactory ensheathing glia (OEG) combined with step training improves hindlimb locomotion in adult rats with a complete spinal cord transection. Spinal cord injury studies use the presence of noradrenergic (NA) axons caudal to the injury site as evidence of axonal regeneration and we previously found more NA axons just caudal to the transection in OEG- ...
متن کاملSerotonergic innervation of the caudal spinal stump in rats after complete spinal transection: effect of olfactory ensheathing glia.
Spinal cord injury studies use the presence of serotonin (5-HT)-immunoreactive axons caudal to the injury site as evidence of axonal regeneration. As olfactory ensheathing glia (OEG) transplantation improves hindlimb locomotion in adult rats with complete spinal cord transection, we hypothesized that more 5-HT-positive axons would be found in the caudal stump of OEG- than media-injected rats. P...
متن کاملLong-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants.
The lack of axonal regeneration in the injured adult mammalian spinal cord leads to permanent functional impairment. To induce axonal regeneration in the transected adult rat spinal cord, we have used the axonal growth-promoting properties of adult olfactory bulb ensheathing glia (EG). Schwann cell (SC)-filled guidance channels were grafted to bridge both cord stumps, and suspensions of pure (9...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2011
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2011.01.007